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Article

Abnormal T cell receptor signal transduction of CD4 Th cells in X-linked lymphoproliferative syndrome.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2001

Nakamura H, Zarycki J, Sullivan J L, Jung J U

Abstract excerpt

The molecular basis of X-linked lymphoproliferative (XLP) disease has been attributed to mutations in the signaling lymphocytic activation molecule-associated protein (SAP), an src homology 2 domain-containing intracellular signaling molecule known to interact with the lymphocyte-activating surface receptors signaling lymphocytic activation molecule and 2B4. To investigate the effect of SAP defects on TCR signal...

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Share to Herpesvirus 4, Human
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Retroviridae Proteins, Oncogenic

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Share to T-Lymphocytes, Helper-Inducer

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Source

Identifiers

PMID: 11509608
DOI: 10.4049/jimmunol.167.5.2657

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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