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Article

The VDAC2-BAK rheostat controls thymocyte survival.

Science signaling - 25 Aug 2009

Ren Decheng, Kim Hyungjin, Tu Ho-Chou, Westergard Todd D, Fisher Jill K, Rubens Jeff A, Korsmeyer Stanley J, Hsieh James J-D, Cheng Emily H-Y

Abstract excerpt

The proapoptotic proteins BAX and BAK constitute the mitochondrial apoptotic gateway that executes cellular demise after integrating death signals. The lethal BAK is kept in check by voltage-dependent anion channel 2 (VDAC2), a mammalian-restricted VDAC isoform. Here, we provide evidence showing a critical role for the VADC2-BAK complex in determining thymocyte survival in vivo. Genetic depletion of Vdac2 in the...

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Source

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Identifiers

PMID: 19706873
DOI: 10.1126/scisignal.2000274
PMCID: PMC3842237

Genes

VDAC2
BAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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