Article
Mutant T cell lines as model systems for the dissection of T cell antigen receptor signaling pathways.
Immunologic research - 1 Jan 2000
Abraham R T
Abstract excerpt
T cell antigen receptor (TCR) ligation triggers a cascade of intracellular signaling events that culminate in T cell activation, cytokine gene expression, differentiation, or apoptosis. Many of the enzymes and adapter proteins responsible for signal propagation from the cell surface TCR to the cytoplasm and nucleus have now been identified and molecularly cloned. However, a comprehensive understanding of the...
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