Article
Characterization of a mutant T-cell hybridoma line with defects in the TCR-mediated apoptotic pathway.
Cell death and differentiation - 1 Jan 1999
Morgan G, Smith S, Pak J, Marshak-Rothstein A, Fissore R, Osborne B
Abstract excerpt
A mutant T-cell hybridoma line named mutant 51 was developed that, unlike the parental line, did not die after T-cell receptor (TCR) engagement and demonstrated reduced death in response to dexamethasone. Intracellular calcium measurements showed that available calcium stores were markedly reduced in the mutant cell line. Unlike control cells, secretion of IL-2 from mutant cells was also greatly reduced, although...
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