Octamerization of lambda CI repressor is needed for effective repression of P(RM) and efficient switching from lysogeny.

doi:10.1101/gad.937301

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Octamerization of lambda CI repressor is needed for effective repression of P(RM) and efficient switching from lysogeny.

Genes & development - 15 Nov 2001

Dodd I B, Perkins A J, Tsemitsidis D, Egan J B

Abstract excerpt

The CI repressor of bacteriophage lambda is a model for the role of cooperativity in the efficient functioning of genetic switches. Pairs of CI dimers interact to cooperatively occupy adjacent operator sites at O(R) and at O(L). These CI tetramers repress the lytic promoters and activate transcription of the cI gene from P(RM). CI is also able to octamerize, forming a large DNA loop between O(R) and O(L), but the...

Topics

Bacteriophage lambda
Base Sequence
Blotting, Western
DNA
DNA-Binding Proteins
Dimerization
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Genes, Reporter
Kinetics
Lac Operon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lysogeny

Models, Biological

Molecular Sequence Data

Mutation

Oxygen

Plasmids

Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 11711436
DOI: 10.1101/gad.937301
PMCID: PMC312832

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Octamerization of lambda CI repressor is needed for effective repression of P(RM) and efficient switching from lysogeny.PMID 11711436Read ↗

Cro's role in the CI Cro bistable switch is critical for {lambda}'s transition from lysogeny to lytic development.Semantic proximity Read ↗

Role of the lytic repressor in prophage induction of phage lambda as analyzed by a module-replacement approach.Semantic proximity Read ↗

Cooperative DNA binding by CI repressor is dispensable in a phage lambda variant.Semantic proximity Read ↗

New Insights into the Phage Genetic Switch: Effects of Bacteriophage Lambda Operator Mutations on DNA Looping and Regulation of PR, PL, and PRM.Semantic proximity Read ↗

Binding cooperativity in phage lambda is not sufficient to produce an effective switch.Semantic proximity Read ↗

The three operators of the lac operon cooperate in repression.Semantic proximity Read ↗

Coupled energetics of lambda cro repressor self-assembly and site-specific DNA operator binding II: cooperative interactions of cro dimers.Semantic proximity Read ↗

The role of MOR and the CI operator sites on the genetic switch of the temperate bacteriophage TP901-1.Semantic proximity Read ↗

The activation defect of a lambda cI positive control mutant.Semantic proximity Read ↗

Dimeric lac repressors exhibit phase-dependent co-operativity.Semantic proximity Read ↗

Operator-bound GalR dimers close DNA loops by direct interaction: tetramerization and inducer binding.Semantic proximity Read ↗

In vivo non-specific binding of lambda CI and Cro repressors is significant.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.