Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dimeric lac repressors exhibit phase-dependent co-operativity.

Journal of molecular biology - 11 Dec 1998

Müller J, Barker A, Oehler S, Müller-Hill B

Abstract excerpt

Transcription of the lac operon in Escherichia coli is repressed by the binding of Lac repressor (LacR) to lac operator O1, a pseudo-palindromic sequence centred 11 bp downstream of the transcription start. Full repression of the wild-type promoter by wild-type, tetrameric LacR requires the presence of at least two operator sequences that must not only be in close proximity to O1, 401 bp and 92 bp for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Bacterial Proteins
Share to DNA, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Molecular Sequence Data

Share to Mutation

Share to Promoter Regions, Genetic

Share to Protein Conformation

Source

Identifiers

PMID: 9837708
DOI: 10.1006/jmbi.1998.2253

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dimeric lac repressors exhibit phase-dependent co-operativity.PMID 9837708Read ↗

The three operators of the lac operon cooperate in repression.Semantic proximity Read ↗

In vitro repression of the gal promoters by GalR and HU depends on the proper helical phasing of the two operators.Semantic proximity Read ↗

Operator-bound GalR dimers close DNA loops by direct interaction: tetramerization and inducer binding.Semantic proximity Read ↗

Octamerization of lambda CI repressor is needed for effective repression of P(RM) and efficient switching from lysogeny.Semantic proximity Read ↗

The essential role of the promoter-proximal subunit of CAP in pap phase variation: Lrp- and helical phase-dependent activation of papBA transcription by CAP from -215.Semantic proximity Read ↗

Three-stage regulation of the amphibolic gal operon: from repressosome to GalR-free DNA.Semantic proximity Read ↗

Operator search by mutant Lac repressors.Semantic proximity Read ↗

The transcriptional regulator GalR self-assembles to form highly regular tubular structures.Semantic proximity Read ↗

New Insights into the Phage Genetic Switch: Effects of Bacteriophage Lambda Operator Mutations on DNA Looping and Regulation of PR, PL, and PRM.Semantic proximity Read ↗

Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor.Semantic proximity Read ↗

Wild-type operator binding and altered cooperativity for inducer binding of lac repressor dimer mutant R3.Semantic proximity Read ↗

Effect of lac repressor oligomerization on regulatory outcome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.