Article
Dimeric lac repressors exhibit phase-dependent co-operativity.
Journal of molecular biology - 11 Dec 1998
Müller J, Barker A, Oehler S, Müller-Hill B
Abstract excerpt
Transcription of the lac operon in Escherichia coli is repressed by the binding of Lac repressor (LacR) to lac operator O1, a pseudo-palindromic sequence centred 11 bp downstream of the transcription start. Full repression of the wild-type promoter by wild-type, tetrameric LacR requires the prese...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- DNA, Bacterial
- Dimerization
- Escherichia coli
- Escherichia coli Proteins
- Lac Operon
- Lac Repressors
- Molecular Sequence Data
- Mutation
- Operator Regions, Genetic
- Promoter Regions, Genetic
- Protein Conformation
- Repressor Proteins