Article
Coupled energetics of lambda cro repressor self-assembly and site-specific DNA operator binding II: cooperative interactions of cro dimers.
Journal of molecular biology - 22 Sept 2000
Darling P J, Holt J M, Ackers G K
Abstract excerpt
The bacteriophage lambda relies on interactions of the cI and cro repressors which self assemble and bind the two operators (O(R) and O(L)) of the phage genome to control the lysogenic to lytic switch. While the self assembly and O(R) binding of cI have been investigated in detail, a more complete understanding of gene regulation by phage lambda also requires detailed knowledge of the role of cro repressor as it...
Topics
- Allosteric Site
- Bacteriophage lambda
- DNA Footprinting
- DNA, Bacterial
- DNA-Binding Proteins
- Deoxyribonuclease I
- Dimerization
- Gene Expression Regulation, Bacterial
- Models, Genetic
- Mutation
- Operator Regions, Genetic
- Protein Binding
- Repressor Proteins
- Reproducibility of Results