New Insights into the Phage Genetic Switch: Effects of Bacteriophage Lambda Operator Mutations on DNA Looping and Regulation of PR, PL, and PRM.

doi:10.1016/j.jmb.2016.08.027

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Article

New Insights into the Phage Genetic Switch: Effects of Bacteriophage Lambda Operator Mutations on DNA Looping and Regulation of PR, PL, and PRM.

Journal of molecular biology - 6 Nov 2016

Lewis Dale E A, Gussin Gary N, Adhya Sankar

Abstract excerpt

One of the best understood systems in genetic regulatory biology is the so-called "genetic switch" that determines the choice the phage-encoded CI repressor binds cooperatively to tripartite operators, OL and OR, in a defined pattern, thus blocking the transcription at two lytic promoters, PL and PR, and auto-regulating the promoter, PRM, which directs CI synthesis by the prophage. Fine-tuning of the maintenance...

Topics

Bacteriophage lambda
DNA, Viral
Gene Expression Regulation, Viral
Lysogeny
Mutation
Nucleic Acid Conformation
Operator Regions, Genetic
Promoter Regions, Genetic
Protein Binding
Repressor Proteins
Transcription, Genetic
Virus Activation

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Identifiers

PMID: 27670714
DOI: 10.1016/j.jmb.2016.08.027
PMCID: PMC7757127

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