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Article

In vivo non-specific binding of lambda CI and Cro repressors is significant.

FEBS letters - 9 Apr 2004

Bakk Audun, Metzler Ralf

Abstract excerpt

We propose a thermodynamic model that includes the non-specific binding of the lambda phage regulatory proteins CI and Cro. By fitting the model to experimental in vivo data on activities of the two promoters P(RM) and P(R) versus concentration, we estimate the free energy upon non-specific binding to be -4.1+/-0.9 kcal/mol for CI and -4.2+/-0.8 kcal/mol for Cro. For concentrations >100 nM of CI or Cro, we find...

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Share to Bacteriophage lambda
Share to Gene Expression Regulation, Viral
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Promoter Regions, Genetic

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Source

Identifiers

PMID: 15063724
DOI: 10.1016/S0014-5793(04)00249-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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