The activation defect of a lambda cI positive control mutant.

doi:10.1006/jmbi.1996.0735

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Article

The activation defect of a lambda cI positive control mutant.

Journal of molecular biology - 24 Jan 1997

Whipple F W, Ptashne M, Hochschild A

Abstract excerpt

"Positive control" mutants of the cI protein of bacteriophage lambda (lambda cI) bind DNA but, unlike the wild-type protein, fail to activate transcription. According to the original interpretation of Ptashne and co-workers, these mutants bear amino acid substitutions that disrupt a stimulatory i...

Topics

Bacteriophage lambda
Cross Reactions
DNA Footprinting
DNA-Binding Proteins
Deoxyribonuclease I
Isopropyl Thiogalactoside
Mutation
Promoter Regions, Genetic
Recombinant Proteins
Repressor Proteins
Transcriptional Activation
Viral Proteins
Viral Regulatory and Accessory Proteins

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