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Article

Cro's role in the CI Cro bistable switch is critical for {lambda}'s transition from lysogeny to lytic development.

Genes & development - 1 Oct 2007

Schubert Rachel A, Dodd Ian B, Egan J Barry, Shearwin Keith E

Abstract excerpt

CI represses cro; Cro represses cI. This double negative feedback loop is the core of the classical CI-Cro epigenetic switch of bacteriophage lambda. Despite the classical status of this switch, the role in lambda development of Cro repression of the P(RM) promoter for CI has remained unclear. To address this, we created binding site mutations that strongly impaired Cro repression of P(RM) with only minimal...

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Share to Bacteriophage lambda
Share to Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lysogeny

Share to Promoter Regions, Genetic

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Share to Repressor Proteins

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Identifiers

PMID: 17908932
DOI: 10.1101/gad.1584907
PMCID: PMC1993876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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