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Article

Operator-bound GalR dimers close DNA loops by direct interaction: tetramerization and inducer binding.

The EMBO journal - 15 Aug 2002

Semsey Szabolcs, Geanacopoulos Mark, Lewis Dale E A, Adhya Sankar

Abstract excerpt

The assembly of the Gal repressosome, a higher order nucleoprotein complex that represses transcription of the gal operon in Escherichia coli, involves the formation of a DNA loop encompassing the promoter segment. GalR dimers bound to two spatially separated operators, O(E) and O(I), specifically interact with the histone-like protein HU and close the loop in supercoiled DNA. We isolated and characterized a GalR...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Bacterial

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Source

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Identifiers

PMID: 12169637
DOI: 10.1093/emboj/cdf431
PMCID: PMC126169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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