Article
Activator-mediated disruption of sequence-specific DNA contacts by the general transcription factor TFIIB.
Genes & development - 15 Nov 2001
Evans R, Fairley J A, Roberts S G
Abstract excerpt
The transcription factor TFIIB plays a central role in preinitiation complex assembly, providing a bridge between promoter-bound TFIID and RNA Polymerase II. TFIIB possesses sequence-specific DNA-binding ability and interacts with the TFIIB-recognition element (BRE), present in many promoters. Here we show that the BRE suppresses the basal level of transcription elicited by a core promoter, which increases the...
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