Transcriptional activation by TFIIB mutants that are severely impaired in interaction with promoter DNA and acidic activation domains.

doi:10.1128/MCB.17.12.6794

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Article

Transcriptional activation by TFIIB mutants that are severely impaired in interaction with promoter DNA and acidic activation domains.

Molecular and cellular biology - 1 Dec 1997

Chou S, Struhl K

Abstract excerpt

Biochemical experiments indicate that the general transcription factor IIB (TFIIB) can interact directly with acidic activation domains and that activators can stimulate transcription by increasing recruitment of TFIIB to promoters. For promoters at which recruitment of TFIIB to promoters is limi...

Topics

Amino Acid Sequence
Base Sequence
Binding Sites
DNA, Fungal
DNA-Binding Proteins
Fungal Proteins
Genes, Fungal
Herpes Simplex Virus Protein Vmw65
Humans
Molecular Sequence Data
Mutation
Oligonucleotide Probes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Promoter Regions, Genetic

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

TATA-Box Binding Protein

Transcription Factor TFIIB

Transcription Factors

Source

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Identifiers

PMID: 9372910
DOI: 10.1128/MCB.17.12.6794
PMCID: PMC232535

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9372910-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Transcriptional activation by TFIIB mutants that are severely impaired in interaction with promoter DNA and acidic activation domains.PMID 9372910Read ↗

Assembly of transcription factor IIB at a promoter in vivo requires contact with RNA polymerase II.Semantic proximity Read ↗

The TBP-TFIIA interaction in the response to acidic activators in vivo.Semantic proximity Read ↗

A severely defective TATA-binding protein-TFIIB interaction does not preclude transcriptional activation in vivo.Semantic proximity Read ↗

Mutations on the DNA-binding surface of TATA-binding protein can specifically impair the response to acidic activators in vivo.Semantic proximity Read ↗

A role for activator-mediated TFIIB recruitment in diverse aspects of transcriptional regulation.Semantic proximity Read ↗

Minimal promoter systems reveal the importance of conserved residues in the B-finger of human transcription factor IIB.Semantic proximity Read ↗

Association of transcription factor IIA with TATA binding protein is required for transcriptional activation of a subset of promoters and cell cycle progression in Saccharomyces cerevisiae.Semantic proximity Read ↗

TFIIA has activator-dependent and core promoter functions in vivo.Semantic proximity Read ↗

Interaction between an acidic activator and transcription factor TFIIB is required for transcriptional activation.Semantic proximity Read ↗

Requirement for transcription factor IIA (TFIIA)-TFIID recruitment by an activator depends on promoter structure and template competition.Semantic proximity Read ↗

Intramolecular interaction of yeast TFIIB in transcription control.Semantic proximity Read ↗

Core promoter-dependent TFIIB conformation and a role for TFIIB conformation in transcription start site selection.Semantic proximity Read ↗

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