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Article

Inhibition of TATA binding protein dimerization by RNA polymerase III transcription initiation factor Brf1.

The Journal of biological chemistry - 30 Jul 2004

Alexander Diane E, Kaczorowski David J, Jackson-Fisher Amy J, Lowery Drew M, Zanton Sara J, Pugh B Franklin

Abstract excerpt

The Brf1 subunit of TFIIIB plays an important role in recruiting the TATA-binding protein (TBP) to the up-stream region of genes transcribed by RNA polymerase III. When TBP is not bound to promoters, it sequesters its DNA binding domain through dimerization. Promoter assembly factors therefore might be required to dissociate TBP into productively binding monomers. Here we show that Saccharomyces cerevisiae Brf1...

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Identifiers

PMID: 15190063
DOI: 10.1074/jbc.M405782200

Genes

TBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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