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Article

Intramolecular interaction of yeast TFIIB in transcription control.

Nucleic acids research - 1 May 2000

Zhang D Y, Dorsey M J, Voth W P, Carson D J, Zeng X, Stillman D J, Ma J

Abstract excerpt

The general transcription factor TFIIB is a key component in the eukaryotic RNA polymerase II (RNAPII) transcriptional machinery. We have previously shown that a yeast TFIIB mutant (called YR1m4) with four amino acid residues in a species-specific region changed to corresponding human residues affects the expression of genes activated by different activators in vivo. We report here that YR1m4 can interact with...

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Source

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Identifiers

PMID: 10756191
DOI: 10.1093/nar/28.9.1913
PMCID: PMC103289

Genes

TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Intramolecular interaction of yeast TFIIB in transcription control.PMID 10756191Read ↗

Transcriptional activation by TFIIB mutants that are severely impaired in interaction with promoter DNA and acidic activation domains.Semantic proximity Read ↗

TFIIA interacts with TFIID via association with TATA-binding protein and TAF40.Semantic proximity Read ↗

TFIIA has activator-dependent and core promoter functions in vivo.Semantic proximity Read ↗

Disruption of the interaction between TFIIAαβ and TFIIA recognition element inhibits RNA polymerase II gene transcription in a promoter context-dependent manner.Semantic proximity Read ↗

Activator-mediated disruption of sequence-specific DNA contacts by the general transcription factor TFIIB.Semantic proximity Read ↗

Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4.Semantic proximity Read ↗

The yeast RNA polymerase II-associated factor Iwr1p is involved in the basal and regulated transcription of specific genes.Semantic proximity Read ↗

Multiple regions of TBP participate in the response to transcriptional activators in vivo.Semantic proximity Read ↗

Interdependent interactions between TFIIB, TATA binding protein, and DNA.Semantic proximity Read ↗

yTAFII61 has a general role in RNA polymerase II transcription and is required by Gcn4p to recruit the SAGA coactivator complex.Semantic proximity Read ↗

Transcription factor TFIIB sites important for interaction with promoter-bound TFIID.Semantic proximity Read ↗

Functional interchangeability of TFIIIB components from yeast and human cells in vitro.Semantic proximity Read ↗

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