Article
Transcription factor TFIIB sites important for interaction with promoter-bound TFIID.
Science (New York, N.Y.) - 23 Jul 1993
Yamashita S, Hisatake K, Kokubo T, Doi K, Roeder R G, Horikoshi M, Nakatani Y
Abstract excerpt
Transcription initiation factor TFIIB recruits RNA polymerase II to the promoter subsequent to interaction with a preformed TFIID-promoter complex. The domains of TFIIB required for binding to the TFIID-promoter complex and for transcription initiation have been determined. The carboxyl-terminal two-thirds of TFIIB, which contains two direct repeats and two basic residue repeats, is sufficient for interaction...
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