Article
Direct modulation of RNA polymerase core functions by basal transcription factors.
Molecular and cellular biology - 1 Sept 2005
Werner Finn, Weinzierl Robert O J
Abstract excerpt
Archaeal RNA polymerases (RNAPs) are recruited to promoters through the joint action of three basal transcription factors: TATA-binding protein, TFB (archaeal homolog of TFIIB), and TFE (archaeal homolog of TFIIE). Our results demonstrate several new insights into the mechanisms of TFB and TFE during the transcription cycle. (i) The N-terminal Zn ribbon of TFB displays a surprising degree of redundancy for the...
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