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Article

A role for activator-mediated TFIIB recruitment in diverse aspects of transcriptional regulation.

Current biology : CB - 1 May 1995

Roberts S G, Choy B, Walker S S, Lin Y S, Green M R

Abstract excerpt

BACKGROUND: Transcription by RNA polymerase II in eukaryotic cells requires the ordered assembly of general transcription factors on the promoter to form a preinitiation complex. Transcriptional activator proteins (activators) stimulate transcription by increasing the rate and/or extent of preinitiation complex assembly. We have shown previously that acidic activators increase the stable association of TFIIB on...

Topics

Gene Expression Regulation
Mutation
Trans-Activators
Transcription Factor TFIIB
Transcription Factors
Transcription, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7583100
DOI: 10.1016/s0960-9822(95)00103-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7583100-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A role for activator-mediated TFIIB recruitment in diverse aspects of transcriptional regulation.PMID 7583100Read ↗

Interaction between an acidic activator and transcription factor TFIIB is required for transcriptional activation.Semantic proximity Read ↗

Activator-induced conformational change in general transcription factor TFIIB.Semantic proximity Read ↗

Activator-mediated disruption of sequence-specific DNA contacts by the general transcription factor TFIIB.Semantic proximity Read ↗

Core promoter-dependent TFIIB conformation and a role for TFIIB conformation in transcription start site selection.Semantic proximity Read ↗

Transcriptional activation by TFIIB mutants that are severely impaired in interaction with promoter DNA and acidic activation domains.Semantic proximity Read ↗

Assembly of transcription factor IIB at a promoter in vivo requires contact with RNA polymerase II.Semantic proximity Read ↗

Transcription factors use a unique combination of cofactors to potentiate different promoter-dependent steps in transcriptionSemantic proximity Read ↗

The role of TFIIB-RNA polymerase II interaction in start site selection in yeast cells.Semantic proximity Read ↗

RNA-binding proteins activate transcription through defined molecular grammarsSemantic proximity Read ↗

Dynamics of global histone acetylation and deacetylation in vivo: rapid restoration of normal histone acetylation status upon removal of activators and repressors.Semantic proximity Read ↗

Transcription factor TFIIB sites important for interaction with promoter-bound TFIID.Semantic proximity Read ↗

Interaction of the TFIIB zinc ribbon with RNA polymerase II.Semantic proximity Read ↗

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