INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas.

doi:10.1038/sj.onc.1204902

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Article

INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas.

Oncogene - 25 Oct 2001

Tannapfel A, Busse C, Weinans L, Benicke M, Katalinic A, Geissler F, Hauss J, Wittekind C

Abstract excerpt

The INK4a-ARF (CDKN2A)- locus on chromosome 9p21 encodes for two tumour suppressor proteins, p16(INK4a) and p14(ARF), that act as upstream regulators of the Rb-CDK4 and p53 pathways. To study the contribution of each pathway in tumorigenesis of hepatocellular carcinoma (HCC), we analysed the alterations of p14(ARF), p16(INC4a) and p53. After microdissection, DNA of 71 hepatocellular carcinomas was analysed for...

Topics

Adult
Carcinoma, Hepatocellular
Chromosomes, Human, Pair 9
CpG Islands
Cyclin-Dependent Kinase Inhibitor p16
DNA Methylation
DNA Mutational Analysis
DNA, Neoplasm
Exons
Female
Gene Silencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, p16

Genes, p53

Humans

Liver Cirrhosis

Liver Neoplasms

Male

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 11704835
DOI: 10.1038/sj.onc.1204902

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-11704835-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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