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Article

Somatic INK4a-ARF locus mutations: a significant mechanism of gene inactivation in squamous cell carcinomas of the head and neck.

Molecular carcinogenesis - 1 Jan 2001

Poi M J, Yen T, Li J, Song H, Lang J C, Schuller D E, Pearl D K, Casto B C, Tsai M D, Weghorst C M

Abstract excerpt

The INK4a-ARF locus is located on human chromosome 9p21 and is known to encode two functionally distinct tumor-suppressor genes. The p16(INK4a) (p16) tumor-suppressor gene product is a negative regulator of cyclin-dependent kinases 4 and 6, which in turn positively regulate progression of mammalian cells through the cell cycle. The p14(ARF) tumor-suppressor gene product specifically interacts with human double...

Topics

Base Sequence
Carcinoma, Squamous Cell
Cyclin-Dependent Kinase Inhibitor p16
DNA Primers
Head and Neck Neoplasms
Helminth Proteins
Humans
Muscle Proteins
Mutagenesis, Site-Directed
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Magnetic Resonance, Biomolecular

Polymerase Chain Reaction

Polymorphism, Single-Stranded Conformational

Source

Identifiers

PMID: 11255261
DOI: 10.1002/1098-2744(200101)30:1<26::aid-mc1010>3.0.co;2-e

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-11255261-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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