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Article

Methylation status of p14ARF, p15INK4b, and p16INK4a genes in human hepatocellular carcinoma

11 Nov 2005

Abstract excerpt

BACKGROUND: The INK4 locus consisting of three genes involved in the regulation of cell cycle, p16INK4a, p15INK4b, and p14ARF is often disrupted in human neoplasms. METHODS: We analyzed the promoter methylation of each gene by methylation-specific PCR in hepatocellular carcinoma (HCC). RESULTS: The methylation of p16INK4a, p15INK4b, and p14ARF was found to occur in 27 (69.2%), seven (17.9%), and none out of 39...

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Identifiers

PMID: 16343074
DOI: 10.1111/j.1478-3231.2005.01162.x

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