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Article

Reciprocal relationship between methylation status and loss of heterozygosity at the p14(ARF) locus in Australian and South African hepatocellular carcinomas.

Journal of gastroenterology and hepatology - 1 Mar 2002

Herath Nirmitha I, Kew Michael C, Walsh Michael D, Young Joanne, Powell Lawrie W, Leggett Barbara A, MacDonald Graeme A

Abstract excerpt

Chromosome 9p21, a locus comprising the tumor suppressor genes (TSG) p16(INK4a) and p14(ARF), is a common region of loss of heterozygosity (LOH) in hepatocellular carcinoma (HCC). p14(ARF) shares exon 2 with p16 in a different reading frame. p14 binds to MDM2 resulting in a stabilization of functional p53. This study examined the roles of p14, p16 and p53 in hepatocarcinogenesis, in 37 Australian and 24 South...

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Share to Carcinoma, Hepatocellular
Share to Chromosomes, Human, Pair 9

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p16

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Source

Identifiers

PMID: 11982701
DOI: 10.1046/j.1440-1746.2002.02704.x

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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