Reciprocal relationship between methylation status and loss of heterozygosity at the p14(ARF) locus in Australian and South African hepatocellular carcinomas.

doi:10.1046/j.1440-1746.2002.02704.x

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Article

Reciprocal relationship between methylation status and loss of heterozygosity at the p14(ARF) locus in Australian and South African hepatocellular carcinomas.

Journal of gastroenterology and hepatology - 1 Mar 2002

Herath Nirmitha I, Kew Michael C, Walsh Michael D, Young Joanne, Powell Lawrie W, Leggett Barbara A, MacDonald Graeme A

Abstract excerpt

Chromosome 9p21, a locus comprising the tumor suppressor genes (TSG) p16(INK4a) and p14(ARF), is a common region of loss of heterozygosity (LOH) in hepatocellular carcinoma (HCC). p14(ARF) shares exon 2 with p16 in a different reading frame. p14 binds to MDM2 resulting in a stabilization of functional p53. This study examined the roles of p14, p16 and p53 in hepatocarcinogenesis, in 37 Australian and 24 South...

Topics

Adult
Carcinoma, Hepatocellular
Chromosomes, Human, Pair 9
Cyclin-Dependent Kinase Inhibitor p16
Female
Genes, Tumor Suppressor
Helminth Proteins
Humans
Liver Neoplasms
Loss of Heterozygosity
Male
Methylation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Muscle Proteins

Mutation

Polymerase Chain Reaction

Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 11982701
DOI: 10.1046/j.1440-1746.2002.02704.x

Genes

MDM2

Provenance

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