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Article

Genetic alterations of p16INK4a and p14ARF genes in human bladder cancer.

The Journal of urology - 1 Aug 2003

Chang Lin-Li, Yeh Wen-Ting, Yang Shu-Yuan, Wu Wen-Jeng, Huang Chun-Hsiung

Abstract excerpt

PURPOSE: The growth suppressive genes p16INK4a and p14ARF located on the 9p21 gene cluster have active roles in the Rb and p53 growth control pathways, respectively. p16INK4a is a cyclin dependent kinase inhibitor functioning upstream of Rb. p14ARF restrains cell growth by abrogating Mdm2 inhibition of p53 activity, thereby, facilitating p53 mediated cell cycle arrest and apoptosis. To elucidate specific targets...

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Identifiers

PMID: 12853838
DOI: 10.1097/01.ju.0000067626.37837.3e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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