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Article

p16 is a major inactivation target in hepatocellular carcinoma

1 Jul 2000

Abstract excerpt

BACKGROUND: The p16(INK4A) gene encodes 2 cell cycle regulator proteins, p16 and p14(ARF), by alternative splicing. This genetic locus also contains another cell cycle regulator gene, p15(INK4B), which encodes p15. The inactivation of the p16 protein has been demonstrated in some hepatocellular carcinomas (HCCs); however, the inactivation of the other 2 cell regulator proteins and their inactivation patterns are...

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PMID: 10897001
DOI: 10.1002/1097-0142(20000701)89:1<60::aid-cncr9>3.0.co;2-3

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p16 is a major inactivation target in hepatocellular carcinomaPMID 10897001Read ↗

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