Pathogenetic and biologic significance of TP14ARF alterations in nonsmall cell lung carcinoma.

doi:10.1016/s0165-4608(02)00645-3

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Article

Pathogenetic and biologic significance of TP14ARF alterations in nonsmall cell lung carcinoma.

Cancer genetics and cytogenetics - 1 Feb 2003

Park Myung-Jae, Shimizu Kimihiro, Nakano Tetsuhiro, Park Yong Bum, Kohno Takashi, Tani Masachika, Yokota Jun

Abstract excerpt

The INK4a/ARF locus on human chromosome band 9p21 carries two tumor suppressor genes, TP14ARF and TP16INK4a, and both are frequently inactivated in nonsmall cell lung carcinoma (NSCLC. TP14ARF and TP16INK4a play important roles in the TP53 and RB tumor suppressor pathways, respectively. To elucid...

Topics

Blotting, Western
Carcinoma, Non-Small-Cell Lung
Cell Cycle
Cyclin-Dependent Kinase Inhibitor p16
DNA Methylation
Gene Deletion
Gene Expression Regulation, Neoplastic
Humans
Lung Neoplasms
Mutation
Polymorphism, Single-Stranded Conformational
RNA, Messenger
Reverse Transcriptase Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 12581892
DOI: 10.1016/s0165-4608(02)00645-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-12581892-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Transfection

Tumor Cells, Cultured

Tumor Suppressor Protein p14ARF

Tumor Suppressor Protein p53