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Article

Pathogenetic and biologic significance of TP14ARF alterations in nonsmall cell lung carcinoma.

Cancer genetics and cytogenetics - 1 Feb 2003

Park Myung-Jae, Shimizu Kimihiro, Nakano Tetsuhiro, Park Yong Bum, Kohno Takashi, Tani Masachika, Yokota Jun

Abstract excerpt

The INK4a/ARF locus on human chromosome band 9p21 carries two tumor suppressor genes, TP14ARF and TP16INK4a, and both are frequently inactivated in nonsmall cell lung carcinoma (NSCLC. TP14ARF and TP16INK4a play important roles in the TP53 and RB tumor suppressor pathways, respectively. To elucidate the genetic and epigenetic status of the TP14ARF and TP16INK4a genes in NSCLC, we comprehensively analyzed...

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PMID: 12581892
DOI: 10.1016/s0165-4608(02)00645-3

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Pathogenetic and biologic significance of TP14ARF alterations in nonsmall cell lung carcinoma.PMID 12581892Read ↗

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