Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

INK4a-ARF alterations and p53 mutations in primary and consecutive squamous cell carcinoma of the head and neck.

Virchows Archiv : an international journal of pathology - 1 Aug 2002

Weber Anette, Bellmann Ulf, Bootz Friedrich, Wittekind Christian, Tannapfel Andrea

Abstract excerpt

BACKGROUND: The INK4a-ARF (CDKN2A) locus, located on chromosome 9p21, encodes two functionally distinct tumor suppressor genes, p14(ARF) and p16(INK4a), that play active roles in the p53 and Rb tumor suppressive pathways, respectively. We analyzed the alterations of p14(ARF), p16(INK4a) and p53 to study the contribution of each pathway in tumorigenesis of 29 patients with primary and consecutive (second primary)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, p53

Share to Head and Neck Neoplasms

Share to Neoplasm Recurrence, Local

Share to Neoplasms, Second Primary

Share to RNA, Neoplasm

Share to Tumor Suppressor Protein p14ARF

Source

Identifiers

PMID: 12189502
DOI: 10.1007/s00428-002-0637-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

INK4a-ARF alterations and p53 mutations in primary and consecutive squamous cell carcinoma of the head and neck.PMID 12189502Read ↗

Somatic INK4a-ARF locus mutations: a significant mechanism of gene inactivation in squamous cell carcinomas of the head and neck.Semantic proximity Read ↗

INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas.Semantic proximity Read ↗

p14ARF genetic polymorphisms and susceptibility to second primary malignancy in patients with index squamous cell carcinoma of the head and neck.Semantic proximity Read ↗

Aberrations of the p14(ARF) and p16(INK4a) genes in renal cell carcinomas.Semantic proximity Read ↗

Differential Roles of p16INK4A and p14ARF Genes in Prognosis of Oral CarcinomaSemantic proximity Read ↗

Frequent alterations of the p14(ARF) and p16(INK4a) genes in primary central nervous system lymphomas.Semantic proximity Read ↗

Genetic and methylation status of CDKN2A (p14ARF/p16INK4A) and TP53 genes in recurrent respiratory papillomatosis.Semantic proximity Read ↗

Genetic status of cell cycle regulators in squamous cell carcinoma of the oesophagus: the CDKN2A (p16(INK4a) and p14(ARF) ) and p53 genes are major targets for inactivation.Semantic proximity Read ↗

Immunohistochemical [corrected] detection of the alternate INK4a-encoded tumor suppressor protein p14(ARF) in archival human cancers and cell lines using commercial antibodies: correlation with p16(INK4a) expression.Semantic proximity Read ↗

Fine-Mapping Loss of Gene Architecture at the CDKN2B (p15INK4b), CDKN2A (p14ARF, p16INK4a), and MTAP Genes in Head and Neck Squamous Cell CarcinomaSemantic proximity Read ↗

The ARF-p16 gene locus in carcinogenesis and therapy of head and neck squamous cell carcinoma.Semantic proximity Read ↗

Epigenetic changes in the <i>CDKN2A</i> locus are associated with differential expression of P16INK4A and P14ARF in HPV‐positive oropharyngeal squamous cell carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.