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Article

INK4a-ARF alterations in liver cell adenoma.

Gut - 1 Aug 2002

Tannapfel A, Busse C, Geissler F, Witzigmann H, Hauss J, Wittekind C

Abstract excerpt

BACKGROUND: The INK4a-ARF (CDKN2A) locus on chromosome 9p21 encodes two tumour suppressor proteins, p16(INK4a) and p14(ARF), whose functions are inactivated in many human cancers. AIMS: To evaluate p14(ARF) and p16(INK4a) alterations in liver cell adenoma. METHODS: After microdissection, DNA from 25 liver cell adenomas and corresponding normal liver tissue were analysed for INK4-ARF inactivation by DNA sequence...

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Identifiers

PMID: 12117890
DOI: 10.1136/gut.51.2.253
PMCID: PMC1773297

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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