Inactivation of the INK4A/ARF locus frequently coexists with TP53 mutations in non-small cell lung cancer.

doi:10.1038/sj.onc.1203003

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Article

Inactivation of the INK4A/ARF locus frequently coexists with TP53 mutations in non-small cell lung cancer.

Oncogene - 21 Oct 1999

Sanchez-Cespedes M, Reed A L, Buta M, Wu L, Westra W H, Herman J G, Yang S C, Jen J, Sidransky D

Abstract excerpt

Inactivation of the P16 (INK4A)/retinoblastoma (RB) or TP53 biochemical pathway is frequent event in most human cancers. Recent evidence has shown that P14ARF binds to MDM2 leading to an increased availability of wild type TP53 protein. Functional studies also support a putative tumor suppressor...

Topics

Carcinoma, Non-Small-Cell Lung
Cyclin-Dependent Kinase Inhibitor p16
Humans
Lung Neoplasms
Mutation
Proteins
Tumor Suppressor Protein p14ARF
Tumor Suppressor Protein p53

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