Article
MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects.
Pharmaceutical research - 1 Oct 2001
Sakaeda T, Nakamura T, Horinouchi M, Kakumoto M, Ohmoto N, Sakai T, Morita Y, Tamura T, Aoyama N, Hirai M, Kasuga M, Okumura K
Abstract excerpt
PURPOSE: To evaluate the MDR1 genotype frequency in the Japanese population and to study the relationship between the MDR1 genotype and the pharmacokinetics of digoxin after single oral administration in healthy subjects. METHODS: The MDR1 genotype at exon 26 was determined in 114 healthy volunteers by polymerase chain reaction-restriction fragment length polymorphism. The serum concentration-time profile of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.