Article
Common ATP-binding cassette B1 variants are associated with increased digoxin serum concentration.
Pharmacogenetics and genomics - 1 Apr 2008
Aarnoudse Albert-Jan L H J, Dieleman Jeanne P, Visser Loes E, Arp Pascal P, van der Heiden Ilse P, van Schaik Ron H N, Molokhia Mariam, Hofman Albert, Uitterlinden André G, Stricker Bruno H Ch
Abstract excerpt
BACKGROUND AND OBJECTIVE: Digoxin is a known substrate of ATP-binding cassette B1 (ABCB1/MDR1). The results of studies on the association between ABCB1 polymorphisms and digoxin kinetics, however, remain contradictory. Almost all studies were small and involved only single dose kinetics. The goal of this study was to establish ABCB1 genotype effect on digoxin blood concentrations in a large cohort of chronic...
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