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Article

Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs

1 Jul 2003

Abstract excerpt

The multi-drug resistant transporter MDR1/P-glycoprotein, the gene product of MDR1, is a glycosylated membrane protein of 170 kDa, belonging to the ATP-binding cassette (ABC) superfamily of membrane transporters. MDR1 was originally isolated from resistant tumor cells as part of the mechanism of multi-drug resistance, but over the last decade, it has been elucidated that human MDR1 is also expressed throughout...

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PMID: 12831320
DOI: 10.1517/phgs.4.4.397.22747

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