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Article

[MDR1 genotypes related to pharmacokinetics and MDR1 expression].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan - 1 Sept 2003

Nakamura Tsutomu

Abstract excerpt

The multidrug-resistant transporter encoded by the MDR1 gene belongs to the ATP-binding cassette superfamily of membrane transporters. It is involved not only in the acquisition of multidrug-resistance phenotypes in cancer cells but also in normal tissues such as the brain, kidneys, liver, and intestines. This transporter has the potential to export unnecessary or toxic exogenous substances or metabolites, and in...

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Share to ATP-Binding Cassette Transporters
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14513768
DOI: 10.1248/yakushi.123.773

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