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Article

Digoxin pharmacokinetics and MDR1 genetic polymorphisms.

European journal of clinical pharmacology - 1 Apr 2003

Verstuyft Céline, Schwab Mathias, Schaeffeler Elke, Kerb Reinhold, Brinkmann Ulrich, Jaillon Patrice, Funck-Brentano Christian, Becquemont Laurent

Abstract excerpt

BACKGROUND: The effect of MDR1 C3435T single nucleotide polymorphism (SNP) in exon 26 on digoxin pharmacokinetics has recently been challenged. OBJECTIVE. To clarify the relationships between MDR1 genetic polymorphisms in exon 26 (C3435T) and 21 (G2677T/A) and digoxin pharmacokinetics. MATERIALS AND METHODS: MDR1 genotypes for C3435T and G2677T/A SNPs were determined in 32 healthy subjects whose single oral dose...

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PMID: 12698307
DOI: 10.1007/s00228-003-0567-5

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