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Article

Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein.

Clinical pharmacology and therapeutics - 1 Aug 2002

Kurata Yasuo, Ieiri Ichiro, Kimura Miyuki, Morita Toshihiro, Irie Shin, Urae Akinori, Ohdo Shigehiro, Ohtani Hisakazu, Sawada Yasufumi, Higuchi Shun, Otsubo Kenji

Abstract excerpt

OBJECTIVE: Our objective was to quantitate the contribution of the genetic polymorphism of the human MDR1 gene to the bioavailability and interaction profiles of digoxin, a substrate of P-glycoprotein. METHODS: The pharmacokinetics of digoxin was studied in 15 healthy volunteers, who were divided into 3 groups (n = 5 each) on the basis of genotyping for the MDR1 gene, in a 4-dose study after single doses of...

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Identifiers

PMID: 12189368
DOI: 10.1067/mcp.2002.126177

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