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Article

Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene.

Clinical pharmacology and therapeutics - 1 Nov 2002

Johne Andreas, Köpke Karla, Gerloff Thomas, Mai Ingrid, Rietbrock Stephan, Meisel Christian, Hoffmeyer Sven, Kerb Reinhold, Fromm Martin F, Brinkmann Ulrich, Eichelbaum Michel, Brockmöller Jürgen, Cascorbi Ingolf, Roots Ivar

Abstract excerpt

OBJECTIVE: We investigated the effect of polymorphisms in the P-glycoprotein (P-gp) MDR1 gene on steady-state pharmacokinetics of digoxin in Caucasians. According to earlier data, homozygous TT of the exon 26 complementary deoxyribonucleic acid (cDNA) 3435C>T polymorphism was associated with low P-gp expression in the human intestine. METHODS: Eight healthy male homozygous carriers of the wild-type exon-26...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12426522
DOI: 10.1067/mcp.2002.129196

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