Article
Allosteric Effects of Dexamethasone and RU486 on Glucocorticoid Receptor-DNA Interactions
1 Jan 2002
Abstract excerpt
The glucocorticoid receptor (GR) is a DNA-binding protein that can regulate the transcription of a large number of genes in a ligand-dependent fashion. Although much progress has been made on the mechanism of transcriptional regulation by GR, a potential allosteric effect of GR-binding ligands on specific GR-DNA interactions is controversial. In this study, gel-shift methods are used to measure the effects of a...