Article
Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement.
Nature - 1 Jan 2000
Godowski P J, Rusconi S, Miesfeld R, Yamamoto K R
Abstract excerpt
Glucocorticoids, a class of steroid hormones, associate specifically with intracellular receptors, facilitating a conformational change that converts the receptor in vitro to a DNA-binding protein and in vivo to a nuclear species that activates a class of transcriptional enhancers termed glucocor...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- DNA-Binding Proteins
- Gene Expression Regulation
- Glucocorticoids
- Mutation
- Rats
- Receptors, Glucocorticoid
- Transcription, Genetic