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Article

Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement.

Nature - 1 Jan 2000

Godowski P J, Rusconi S, Miesfeld R, Yamamoto K R

Abstract excerpt

Glucocorticoids, a class of steroid hormones, associate specifically with intracellular receptors, facilitating a conformational change that converts the receptor in vitro to a DNA-binding protein and in vivo to a nuclear species that activates a class of transcriptional enhancers termed glucocorticoid response elements (GREs). The DNA sequences recognized specifically by the hormone-receptor complex correspond...

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PMID: 3808033
DOI: 10.1038/325365a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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