Article
Comprehensive overview of the structure and regulation of the glucocorticoid receptor.
Endocrine reviews - 1 Aug 2014
Vandevyver Sofie, Dejager Lien, Libert Claude
Abstract excerpt
Glucocorticoids are among the most prescribed drugs worldwide for the treatment of numerous immune and inflammatory disorders. They exert their actions by binding to the glucocorticoid receptor (GR), a member of the nuclear receptor superfamily. There are several GR isoforms resulting from alternative RNA splicing and translation initiation of the GR transcript. Additionally, these isoforms are all subject to...
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