Article
The ligand binding domain controls glucocorticoid receptor dynamics independent of ligand release.
Molecular and cellular biology - 1 Apr 2007
Meijsing Sebastiaan H, Elbi Cem, Luecke Hans F, Hager Gordon L, Yamamoto Keith R
Abstract excerpt
Ligand binding to the glucocorticoid receptor (GR) results in receptor binding to glucocorticoid response elements (GREs) and the formation of transcriptional regulatory complexes. Equally important, these complexes are continuously disassembled, with active processes driving GR off GREs. We found that co-chaperone p23-dependent disruption of GR-driven transcription depended on the ligand binding domain (LBD)....
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