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Article

Insights on Glucocorticoid Receptor Activity Modulation through the Binding of Rigid Steroids

11 Oct 2010

Abstract excerpt

BACKGROUND: The glucocorticoid receptor (GR) is a transcription factor that regulates gene expression in a ligand-dependent fashion. This modular protein is one of the major pharmacological targets due to its involvement in both cause and treatment of many human diseases. Intense efforts have been made to get information about the molecular basis of GR activity. METHODOLOGY/PRINCIPAL FINDINGS: Here, the behavior...

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PMID: 20949009
DOI: 10.1371/journal.pone.0013279

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