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Article

Mutations in the glucocorticoid receptor DNA-binding domain mimic an allosteric effect of DNA.

Journal of molecular biology - 25 Aug 2000

van Tilborg M A, Lefstin J A, Kruiskamp M, Teuben J, Boelens R, Yamamoto K R, Kaptein R

Abstract excerpt

Two previously isolated mutations in the glucocorticoid receptor DNA-binding domain (DBD), S459A and P493R, have been postulated to mimic DNA-induced conformational changes in the glucocorticoid receptor DBD, thereby constitutively triggering an allosteric mechanism in which binding of specific DNA normally induces the exposure of otherwise silent glucocorticoid receptor transcriptional activation surfaces. Here...

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Identifiers

PMID: 10966797
DOI: 10.1006/jmbi.2000.4001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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