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Article

Genome-wide binding potential and regulatory activity of the glucocorticoid receptor's monomeric and dimeric forms.

Nature communications - 31 Mar 2021

Johnson Thomas A, Paakinaho Ville, Kim Sohyoung, Hager Gordon L, Presman Diego M

Abstract excerpt

A widely regarded model for glucocorticoid receptor (GR) action postulates that dimeric binding to DNA regulates unfavorable metabolic pathways while monomeric receptor binding promotes repressive gene responses related to its anti-inflammatory effects. This model has been built upon the characterization of the GRdim mutant, reported to be incapable of DNA binding and dimerization. Although quantitative live-cell...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 33790284
DOI: 10.1038/s41467-021-22234-9
PMCID: PMC8012360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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