Article
DNA binding site sequence directs glucocorticoid receptor structure and activity.
Science (New York, N.Y.) - 17 Apr 2009
Meijsing Sebastiaan H, Pufall Miles A, So Alex Y, Bates Darren L, Chen Lin, Yamamoto Keith R
Abstract excerpt
Genes are not simply turned on or off, but instead their expression is fine-tuned to meet the needs of a cell. How genes are modulated so precisely is not well understood. The glucocorticoid receptor (GR) regulates target genes by associating with specific DNA binding sites, the sequences of which differ between genes. Traditionally, these binding sites have been viewed only as docking sites. Using structural,...
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