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Article

Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans.

1 Jun 1995

Abstract excerpt

Alternative splicing of the human glucocorticoid receptor (hGR) pre-mRNA generates two highly homologous isoforms, termed hGR alpha and hGR beta. hGR alpha is a ligand-activated transcription factor which, in the hormone-bound state, modulates the expression of glucocorticoid-responsive genes by binding to specific glucocorticoid response element (GRE) DNA sequences. In contrast, hGR beta does not bind...

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PMID: 7769088
DOI: 10.1172/jci117943

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