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Article

Suppressor and oncogenic roles of transforming growth factor-beta and its signaling pathways in tumorigenesis.

Advances in cancer research - 1 Jan 2001

Piek E, Roberts A B

Abstract excerpt

Transforming growth factor-beta (TGF-beta) has been implicated in oncogenesis since the time of its discovery almost 20 years ago. The complex, multifunctional activities of TGF-beta endow it with both tumor suppressor and tumor promoting activities, depending on the stage of carcinogenesis and the responsivity of the tumor cell. Dysregulation or alteration of TGF-beta signaling in tumorigenesis can occur at many...

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Identifiers

PMID: 11665716
DOI: 10.1016/s0065-230x(01)83001-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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