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Article

Duel nature of TGF-beta signaling: tumor suppressor vs. tumor promoter.

Current opinion in oncology - 1 Jan 2005

Bachman Kurtis E, Park Ben Ho

Abstract excerpt

PURPOSE OF REVIEW: Transforming growth factor beta type I (TGF-beta) is a ubiquitous cytokine that is well known for its ability to inhibit epithelial cell proliferation. Somatic mutations abrogating the TGF-beta signal transduction pathway are found in many gastrointestinal cancers, confirming its importance as a tumor suppressor. In contrast, many nongastrointestinal epithelial malignancies lack these somatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15608513
DOI: 10.1097/01.cco.0000143682.45316.ae

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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