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Article

The Dual Role of TGFβ in Human Cancer: From Tumor Suppression to Cancer Metastasis

24 Dec 2012

Abstract excerpt

The transforming growth factor-beta (TGFβ) superfamily encompasses widespread and evolutionarily conserved polypeptide growth factors that regulate and orchestrate growth and differentiation in all cell types and tissues. While they regulate asymmetric cell division and cell fate determination during early development and embryogenesis, TGFβ family members play a major regulatory role in hormonal and immune...

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PMID: 27340590
DOI: 10.5402/2012/381428

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