Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alterations in the Smad pathway in human cancers

26 Oct 2011

Abstract excerpt

Members of the TGF-beta superfamily exhibit various biological activities, and perturbations of their signaling are linked to certain clinical disorders including cancer. The role of TGF-beta signaling as a tumor suppressor pathway is best illustrated by the presence of inactivating mutations in genes encoding TGF-beta receptors and Smads in human carcinomas. This perspective is further supported by studies of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic factors in colorectal cancer
Share to Pancreatic and Hepatic Oncology Research
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22201803
DOI: 10.2741/3986

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alterations in the Smad pathway in human cancersPMID 22201803Read ↗

SMAD Proteins in TGF-β Signalling Pathway in Cancer: Regulatory Mechanisms and Clinical ApplicationsSemantic proximity Read ↗

Smad4-mediated TGF-β signaling in tumorigenesisSemantic proximity Read ↗

Role of transforming growth factor-beta signaling in cancer.Semantic proximity Read ↗

Transforming growth factor-beta signaling in cancer.Semantic proximity Read ↗

Exploring TGF-β Signaling in Cancer Progression: Prospects and Therapeutic StrategiesSemantic proximity Read ↗

TGF‐β signaling: A recap of SMAD‐independent and SMAD‐dependent pathwaysSemantic proximity Read ↗

TGF-β signalling and its role in cancer progression and metastasis.Semantic proximity Read ↗

TGF-β SIGNAL TRANSDUCTIONSemantic proximity Read ↗

TGF-beta signaling: a tale of two responses.Semantic proximity Read ↗

Alterations in components of the TGF-β superfamily signaling pathways in human cancerSemantic proximity Read ↗

TGF-β Signaling in Cancer: Mechanisms of Progression and Therapeutic TargetsSemantic proximity Read ↗

The TGF-beta family: signaling pathways, developmental roles, and tumor suppressor activities.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.