TGF-β Family Signaling in Tumor Suppression and Cancer Progression.

doi:10.1101/cshperspect.a022277

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Article

TGF-β Family Signaling in Tumor Suppression and Cancer Progression.

Cold Spring Harbor perspectives in biology - 1 Dec 2017

Seoane Joan, Gomis Roger R

Abstract excerpt

Transforming growth factor-β (TGF-β) induces a pleiotropic pathway that is modulated by the cellular context and its integration with other signaling pathways. In cancer, the pleiotropic reaction to TGF-β leads to a diverse and varied set of gene responses that range from cytostatic and apoptotic tumor-suppressive ones in early stage tumors, to proliferative, invasive, angiogenic, and oncogenic ones in advanced...

Topics

Animals
Apoptosis
Cell Differentiation
Cell Movement
Disease Progression
Epigenesis, Genetic
Humans
Killer Cells, Natural
Macrophages
Mice
Mutation
Neoplasm Invasiveness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Metastasis

Neoplasms

Phosphorylation

Signal Transduction

T-Lymphocytes

Transforming Growth Factor beta

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Identifiers

PMID: 28246180
DOI: 10.1101/cshperspect.a022277
PMCID: PMC5710110

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