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Article

TGF-β Family Signaling in Tumor Suppression and Cancer Progression.

Cold Spring Harbor perspectives in biology - 1 Dec 2017

Seoane Joan, Gomis Roger R

Abstract excerpt

Transforming growth factor-β (TGF-β) induces a pleiotropic pathway that is modulated by the cellular context and its integration with other signaling pathways. In cancer, the pleiotropic reaction to TGF-β leads to a diverse and varied set of gene responses that range from cytostatic and apoptotic tumor-suppressive ones in early stage tumors, to proliferative, invasive, angiogenic, and oncogenic ones in advanced...

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Identifiers

PMID: 28246180
DOI: 10.1101/cshperspect.a022277
PMCID: PMC5710110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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